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Un ARN thérapeutique en action dans les mitochondries

L’équipe 1 a mis au point des nouvelles molécules capables de pénétrer dans les mitochondries de cellules humaines et de diminuer le nombre de molécules d’ADNmt contenant des mutations pathogéniques. Ces molécules sont constituées d'oligoribonucléotides aux capacités anti-réplicatives conjugués au cholestérol via une liaison biodégradable.


Ce travail a été publié dans la revue Biomaterials. Abstract


L’hélicase RECG1 contrôle la dynamique de l’ADN mitochondrial des plantes ; elle bat les cartes et change la donne.

L’équipe 4 de Mitocross a montré que l'ADN hélicase RECG1 d'Arabidopsis est impliquée non seulement dans la réparation de l’ADN mitochondrial mais aussi dans les processus de ségrégation de ce génome. Ces découvertes sont importantes pour la compréhension de l’évolution rapide de l'organisation du génome mitochondrial, et peuvent aussi avoir des intérêts appliqués dans la création d'une diversité variétale liée à la mitochondrie.

Cette étude est publiée dans la revue The Plant Cell. Abstract

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Comment les protéines remplacent les enzymes à ARN au cours de l'évolution

 
Depuis le «monde à ARN» pré-biotique, les protéines ont progressivement remplacé les ARN pour réaliser les activités catalytiques. L'équipe 5 de Mitocross associée à des chercheurs allemands et autrichiens a étudié ce processus en retraçant l'histoire des RNases P chez les eucaryotes.

Cette étude est publiée dans la revue Molecular Biology and Evolution. Abstract

Communiqué de presse de l'Institut des Sciences biologiques du CNRS

 


Un mécanisme inédit de synchronisation de l’expression des génomes nucléaire et mitochondrial

La production d’énergie par la chaîne respiratoire des mitochondries nécessite un assemblage correct de sous-unités protéiques codées séparément par les génomes nucléaire et mitochondrial qui entretiennent un véritable «dialogue» assurant la synchronisation de l’expression de ces protéines. Les équipes d’Hubert Becker au laboratoire de Génétique moléculaire, génomique, microbiologie à l’ université de Strasbourg et de Jean-Paul di Rago à l’Institut de biochimie et génétique cellulaires à Bordeaux, révèlent le rôle central dans ce processus du complexe AME de S. cerevisiae composé de deux aminoacyl-ARNt synthétases et d’une ancre cytoplasmique. En conditions de respiration, l’inhibition de l’expression de l’ancre libère simultanément les deux aminoacyl-ARNt synthétases et leur permet, en se localisant l’une dans le noyau et l’autre dans la mitochondrie, de synchroniser l’expression des sous-unités d’un complexe de la chaine respiratoire.

Cette étude est publiée dans la revue Molecular Cell. Abstract

Communiqué de presse de l'Institut des Sciences biologiques du CNRS


ARN de porine et mitochondries, une association constructive

Siège de la respiration cellulaire, la mitochondrie est une véritable centrale énergétique mais elle est également impliquée dans la mort cellulaire. Ainsi, un nombre croissant de pathologies humaines comme le cancer et certaines maladies neuro-dégénératives est associé à des dysfonctionnements des mitochondries. Anne-Marie Duchêne, maître de conférences de l’université de Strasbourg, et ses collègues de l’Institut de biologie moléculaire des plantes et de l’Institut des sciences du végétal du CNRS, cherchent à comprendre le fonctionnement de cet organite. Ils viennent de mettre en évidence qu’une porine, protéine majeure de la mitochondrie, était traduite à partir de deux ARNs messagers. L’un d’eux, en s’associant aux membranes mitochondriales, modifie la quantité et la morphologie des mitochondries, comme le précise cette étude parue dans PNAS. Abstract

Communiqué de presse de l'Institut des Sciences biologiques du CNRS

This article has been selected as the "paper of the month" in November 2014 by the French Society for Biochemistry and Molecular Biology (SFBBM).



2017

Gualberto JM and Newton KJ (2017)
Plant mitochondrial genomes:dynamics and mechanisms of mutation
Annu. Rev. Plant Biol. . 68:17.1–17.28 doi:10.1146/annurev-arplant-043015-112232 Abstract

2016

Bonnard G, Gobert A, Arrivé M, Pinker F, Salinas-Giegé T and Giegé P (2016)
Transfer RNA maturation in Chlamydomonas mitochondria, chloroplast and the nucleus by a single RNase P protein.
Plant J. 87 (3):270-280. doi:10.1111/tpj.13198 Abstract

Carapito C, Kuhn L, Karim L, Rompais M, Rabilloud T, Schwenzer H, Sissler M (2016)
Two proteomic methodologies for defining N-termini of mature human mitochondrial aminoacyl-tRNA synthetases.
Methods. doi: 10.1016/j.ymeth.2016.10.012. [Epub ahead of print] Abstract

Cardi M, Zaffagnini M, De Lillo A, Castiglia G, Chibani K, Gualberto JM, Rouhier N, Jacquot JP, Esposito S (2016)
Plastidic P2 glucose-6P dehydrogenase from poplar is modulated by thioredoxin m-type: Distinct roles of cysteine residues in redox regulation and NADPH inhibition.
Plant Sci 252:257-266.

Cognat V, Morelle G, Megel C, Lalande S, Molinier J, Vincent T, Small I, Duchene AM, Maréchal-Drouard L (2016)
The nuclear and organellar tRNA-derived RNA fragment population in Arabidopsis thaliana is highly dynamic.
Nucleic acids research. doi:10.1093/nar/gkw1122 Abstract

Dovydenko I, Tarassov I, Venyaminova A, Entelis N (2016)
Method of carrier-free delivery of therapeutic RNA importable into human mitochondria: Lipophilic conjugates with cleavable bonds.
Biomaterials 76:408-417. Abstract

Fernandez-Millan P, Schelcher C, Chihade J, Masquida B, Giegé P, Sauter C (2016)
Transfer RNA: From pioneering crystallographic studies to contemporary tRNA biology.
Arch Biochem Biophys. doi:10.1016/j.abb.2016.03.005 Abstract

Fujii S, Suzuki T, Giegé P, Higashiyama T, Koizuka N, Shikanai T (2016)
The Restorer-of-fertility-like 2 pentatricopeptide repeat protein and RNase P are required for the processing of mitochondrial orf291 RNA in Arabidopsis.
The Plant J. 86 (6):504-513. doi:10.1111/tpj.13185 Abstract

Ibrahim M, Gahoual R, Enkler L, Becker H, Chicher J, Hammann P, Francois YN, Kuhn L, Leize-Wagner E
Improvement of mitochondria extract from Saccharomyces cerevisiae characterization in shotgun proteomics using sheathless capillary electrophoresis coupled to tandem mass spectrometry.
Journal of chromatographic science. doi:10.1093/chromsci/bmw005. Abstract

Lallement PA, Roret T, Tsan P, Gualberto JM, Girardet JM, Didierjean C, Rouhier N, Hecker A (2016)
Insights into ascorbate regeneration in plants: investigating the redox and structural properties of dehydroascorbate reductases from Populus trichocarpa.
The Biochemical journal 473 (6):717-731.  Abstract

Murcha MW, Kubiszewski-Jakubiak S, Teixeira PF, Gugel IL, Kmiec B, Narsai R, Ivanova A, Megel C, Schock A, Kraus S, Berkowitz O, Glaser E, Philippar K, Marechal-Drouard L, Soll J, Whelan J (2016) Plant-specific preprotein and amino acid transporter proteins are required for tRNA import into mitochondria.
Plant physiology 172 (4):2471-2490. doi:10.1104/pp.16.01519 Abstract

Schelcher C, Sauter C, Giegé P (2016)
Mechanistic and structural studies of Protein-Only RNase P compared to ribonucleoproteins reveal the two faces of the same enzymatic activity.
Biomolecules 6 (3). doi:10.3390/biom6030030 Abstract

Xiu Z, Sun F, Shen Y, Zhang X, Jiang R, Bonnard G, Zhang J, Tan BC (2016)
EMPTY PERICARP16 is required for mitochondrial nad2 Intron 4 cis-splicing, complex I assembly and seed development in maize.
Plant J. 85 (4):507-519. doi:10.1111/tpj.13122 Abstract

2015

Apostolidi M, Saad NY, Drainas D, Pournaras S, Becker HD, Stathopoulos C (2015)
A glyS T-box riboswitch with species-specific structural features responding to both proteinogenic and nonproteinogenic tRNAGly isoacceptors.
RNA 21 (10):1790-1806. Abstract

Baleva M, Gowher A, Kamenski P, Tarassov I, Entelis N, Masquida B (2015)
A Moonlighting Human Protein Is Involved in Mitochondrial Import of tRNA.
International journal of molecular sciences 16 (5):9354-9367. Abstract

Dietrich A, Wallet C, Iqbal RK, Gualberto JM, Lotfi F (2015)
Organellar non-coding RNAs: Emerging regulation mechanisms.
Biochimie 117, 48-62. Abstract

Doublet V, Ubrig E, Alioua A, Bouchon D, Marcade I, Marechal-Drouard L (2015)
Large gene overlaps and tRNA processing in the compact mitochondrial genome of the crustacean Armadillidium vulgare.
RNA biology 12 (10):1159-1168. Abstract

Dovydenko I, Heckel AM, Tonin Y, Gowher A, Venyaminova A, Tarassov I, Entelis N (2015)
Mitochondrial targeting of recombinant RNA.
Methods in molecular biology 1265: 209-225 . Abstract

Gualberto JM, Le Ret M, Beator B, Kuhn K (2015)
The RAD52-like protein ODB1 is required for the efficient excision of two mitochondrial introns spliced via first-step hydrolysis.
Nucleic acids research 43 (13):6500-6510. Abstract

Kubiszewski-Jakubiak S, Megel C, Ubrig E, Salinas T, Duchene A-M, Marechal-Drouard L (2015)
In vitro RNA uptake studies in plant mitochondria.
Methods in molecular biology (Clifton, N J ) 1305:45-6. Abstract

Lallement PA, Meux E, Gualberto JM, Dumarcay S, Favier F, Didierjean C, Saul F, Haouz A, Morel-Rouhier M, Gelhaye E, Rouhier N, Hecker A (2015)
Glutathionyl-hydroquinone reductases from poplar are plastidial proteins that deglutathionylate both reduced and oxidized glutathionylated quinones.
FEBS letters 589: 37-44. Abstract

Lechner M, Rossmanith W, Hartmann RK, Tholken C, Gutmann B, Giege P, Gobert A (2015)
Distribution of Ribonucleoprotein and Protein-Only RNase P in Eukarya.
Molecular biology and evolution 32 (12):3186-3193. Abstract

Megel C, Morelle G, Lalande S, Duchene AM, Small I, Marechal-Drouard L (2015)
Surveillance and Cleavage of Eukaryotic tRNAs.
Int. J. Mol. Sci. 16: 1873-1893. Abstract

Mileshina D, Niazi AK, Weber-Lotfi F, Gualberto J, Dietrich A (2015)
Mitochondrial Genetic Manipulation.
In:Somatic Genome Manipulation: Advances, Methods and Applications (Li XQ, Donnelly D, Jensen TG, eds) Chapter 13, pp. 275-321.Springer-Verlag, Berlin, Heidelberg, Germany.

Mileshina D, Niazi AK, Wyszko E, Szymanski M, Val R, Valentin C, Barciszewski J, Dietrich A (2015)
Mitochondrial targeting of catalytic RNAs.
Methods Mol. Biol. 1265, 227-254.

Pinker F, Giegé P, Sauter C (2015)
Crystallization and crystallographic analysis of an Arabidopsis nuclear proteinaceous RNase P
Acta Cristallogr F Struct Mol Commun. 71 : 1372-1377.  Abstract

Salinas-Giegé T, Giegé R, Giegé P (2015)
tRNA biology in mitochondria.
Int. J. Mol. Sci. 16: 4518-4559. Abstract

Sauter C, Lorber B, Gaudry A, Karim L, Schwenzer H, Wien F, Roblin P, Florentz C and Sissler M (2015).
Neurodegenerative disease-associated mutants of a human mitochondrial aminoacyl-tRNA synthetase present individual molecular signatures.
Scientific Reports, 5:17332. Abstract

Scotti N, Sannino L, Idoine A, Hamman P, De Stradis A, Giorio P, Marechal-Drouard L, Bock R, Cardi T (2015) The HIV-1 Pr55 gag polyprotein binds to plastidial membranes and leads to severe impairment of chloroplast biogenesis and seedling lethality in transplastomic tobacco plants.
Transgenic research 24 (2):319-33. Abstract

Simon M, Richard EM, Wang X, Shahzad M, Huang VH, Qaiser TA, Potluri P, Mahl SE, Davila A, Nazli S, Hancock S, Yu M, Gargus J, Chang R, Al-sheqaih N, Newman WG, Abdenur J, Starr A, Hegde R, Dorn T, Busch A, Park E, Wu J, Schwenzer H, Flierl A, Florentz C, Sissler M, Khan SN, Li R, Guan M-X, Friedman TB, Wu DK, Procaccio V, Riazuddin S, Wallace DC, Ahmed ZM, Huang T, Riazuddin S (2015)
Mutations of human NARS2, encoding the mitochondrial asparaginyl-tRNA synthetase, cause nonsyndromic deafness and Leigh Syndrome.
Plos Genetics 11(3):e1005097. Abstract

Sun F, Wang X, Bonnard G, Shen Y, Xiu Z, Li X, Gao D, Zhang Z, Tan BC (2015)
Empty pericarp7 encodes a mitochondrial E-subgroup pentatricopeptide repeat protein that is required for ccmF editing, mitochondrial function and seed development in maize.
The Plant journal 84 (2):283-295. Abstract

Wallet C, Le Ret M, Bergdoll M, Bichara M, Dietrich A, Gualberto JM (2015)
The RECG1 DNA translocase is a key factor in recombination surveillance, repair and segregation of the mitochondrial DNA in Arabidopsis.  
Plant Cell 27, 2907-2925. Abstract

Weber-Lotfi F, Koulintchenko MV, Ibrahim N, Hammann P, Mileshina DV, Konstantinov YM, Dietrich A (2015)
Nucleic acid import into mitochondria: New insights into the translocation pathways.
Biochim. Biophys. Acta 1853, 3165-3181. Abstract

2014

Araiso Y., Huot J.L., Skiguchi T., Frechin M., Fischer F., Enkler L., Senger B., Ishitani R.,  Becker, H.D., NurekiO. (2014).
Crystal structure of Saccharomyces cerevisiae mitochondrial GatFAB reveals a novel subunit assembly in tRNA-dependent amidotransferases.
Nucleic Acids Res.
 42, 6052-6063. Abstract

Atkinson GC, Kuzmenko A, Chicherin I, Soosaar A, Tenson T, Carr M, Kamenski P, Hauryliuk V (2014)
An evolutionary ratchet leading to loss of elongation factors in eukaryotes.
BMC evolutionary biology 14: 35

Couturier J., Wu H.C., Dhalleine T., Pégeot H., Sudre D., Gualberto J.M., Jacquot J.P., Gaymard F., Vignols F. and Rouhier N. (2014).
Monothiol glutaredoxin-BolA interactions: redox control of Arabidopsis thaliana BolA2 and SufE1. 
Mol. Plant 7, 187-205. Abstract

Frechin M, Enkler L, Tetaud E, Laporte D, Senger B, Blancard C, Hammann P, Bader G, Clauder-Munster S, Steinmetz LM, Martin RP, di Rago J, Becker HD (2014)
Expression of Nuclear and Mitochondrial Genes Encoding ATP Synthase Is Synchronized by Disassembly of a Multisynthetase Complex.
Molecular cell 56: 763-776

Gonzalez, D.H. and Giegé P. (2014)
Biogenesis of the oxidative phosphorylation machinery in plants. From gene expression to complex assembly. 
Frontiers in Plant Physiol. 5, 225. Abstract

Gualberto J.M. and Kühn K. (2014).
DNA-binding proteins in plant mitochondria: Implications for transcription.
Mitochondrion, doi:10.1016/j.mito.2014.02.004. Abstract

Gualberto J.M., Mileshina D., Wallet C., Niazi A.K., Weber-Lotfi F. and Dietrich A. (2014).
The plant mitochondrial genome: dynamics and maintenance. 
Biochimie 100: 107-120. Abstract

Hammani K, Barkan A (2014)
An mTERF domain protein functions in group II intron splicing in maize chloroplasts.
Nucleic acids research 42: 5033-5042

Hammani K, Bonnard G, Bouchoucha A, Gobert A, Pinker F, Salinas T, Giegé P (2014)
Helical repeats modular proteins are major players for organelle gene expression.
Biochimie 100: 141-150

Hammani K., Giegé P. (2014).
RNA metabolism in plant mitochondria.
Trends Plant Sci. 19, 380-389. Abstract

Huot J.L., Enkler L., Megel C., Karim L., Laporte D., Becker H., Duchêne A.M., Sissler M. and Maréchal-Drouard L. (2014).
Idiosyncrasies in decoding mitochondrial genomes.
Biochimie 100, 95-106. Abstract

Kondo J., Sauter C. and Masquida B. (2014).
RNA Crystallization.
In Handbook of RNA biochemistry: Second, Completely Revised and Enlarged Edition (Hartmann, R.K., Bindereif, A., Schön, A., Westhof, E., eds.) pp. 481-498.
Wiley-VCH. Abstract

Koulintchenko M.V., Ibrahim N., Klimenko E.S., Konstantinov Yu.M., Weber-Lotfi F. and Dietrich A. (2014).
Specificity of DNA import into isolated mitochondria from plants and mammals.
Biopolym. Cell 30: 68-70.

Kuzmenko A, Atkinson GC, Levitskii S, Zenkin N, Tenson T, Hauryliuk V, Kamenski P (2014)
Mitochondrial translation initiation machinery: conservation and diversification.
Biochimie 100: 132-140

Lallement P.A., Meux E., Gualberto J.M., Prosper P., Didierjean C., Saul F., Haouz A., Rouhier N., Hecker A. (2014).
Structural and enzymatic insights into Lambda glutathione transferases from Populus trichocarpa, monomeric enzymes constituting an early divergent class specific to terrestrial plants.
Biochem J., doi:10.1042/BJ20140390. Abstract

Laporte D, Huot JL, Bader G, Enkler L, Senger B, Becker HD (2014)
Exploring the evolutionary diversity and assembly modes of multi-aminoacyl-tRNA synthetase complexes: Lessons from unicellular organisms.
FEBS letters 588: 4268-4278

Maréchal-Drouard L., Sissler M. and Tarassov I., Eds. (2014).
Mitochondria: An organelle for life.
Biochimie. Elsevier. Abstract

Meyer M, Masquida B (2014)
cis-Acting 5' hammerhead ribozyme optimization for in vitro transcription of highly structured RNAs.
Methods in molecular biology 1086: 21-40 Abstract

Meyer M., Nielsen H., Oliéric V., Roblin P., Johansen S.D., Westhof E., Masquida B. (2014).
Speciation of a group I intron into a lariat capping ribozyme
.
Proc. Natl. Acad. Sci. USA 111, 7659-64. Abstract

Michaud M., Ubrig E., Filleur S., Erhardt M., Ephritikhine G., Marechal-Drouard L. and Duchene A. M. (2014).
Differential targeting of VDAC3 mRNA isoforms influences mitochondria morphology.
Proc Natl Acad Sci U.S.A., 111:8991-6. Abstract
Press Release @ INSB website

Michaud M., Maréchal-Drouard L. and Duchêne A.M. (2014).
Targeting of cytosolic mRNA to mitochondria : naked RNA can bind to the mitochondrial surface.
Biochimie, 100:159-166, 2014. Abstract

Patrushev MV, Kamenski PA, Mazunin IO (2014)
Mutations in mitochondrial DNA and approaches for their correction.
Biochemistry. Biokhimiia 79: 1151-1160

Salinas T, El Farouk-Ameqrane S, Ubrig E, Sauter C, Duchene AM, Marechal-Drouard L (2014)
Molecular basis for the differential interaction of plant mitochondrial VDAC proteins with tRNAs.
Nucleic acids research 42: 9937-9948 Abstract

Salinas T., Larosa V., Cardol P., Maréchal-Drouard L. and Remacle C. (2014).
Respiratory-deficient mutants of the unicellular green alga Chlamydomonas : A review.
Biochimie, 100:207-218, 2014. Abstract

Schwenzer H, Scheper GC, Zorn N, Moulinier L, Gaudry A, Leize E, Martin F, Florentz C, Poch O, Sissler M (2014)
Released selective pressure on a structural domain gives new insights on the functional relaxation of mitochondrial aspartyl-tRNA synthetase.
Biochimie 100: 18-26 Abstract

Schwenzer H, Zoll J, Florentz C, Sissler M (2014)
Pathogenic implications of human mitochondrial aminoacyl-tRNA synthetases.
In: Kim S (ed) Topics in Current Chemistry-Aminoacyl-tRNA Synthetases: Applications in Chemistry, Biology and Medicine. Springer, pp 247-292

Scotti N, Sannino L, Idoine A, Hamman P, De Stradis A, Giorio P, Marechal-Drouard L, Bock R, Cardi T (2014) The HIV-1 Pr55 polyprotein binds to plastidial membranes and leads to severe impairment of chloroplast biogenesis and seedling lethality in transplastomic tobacco plants. Transgenic research

Tang Y, Nielsen H, Masquida B, Gardner PP, Johansen SD (2014)
Molecular characterization of a new member of the lariat capping twin-ribozyme introns.
Mobile DNA 5: 25

Tonin Y, Entelis N (2014)
Maladies Mitochondriales et Stratégies Thérapeutiques
.
Sci. Med., 30 (12) :1101-9

Tonin Y., Heckel A.-M., Vysokikh M., Dovydenko I., Meschaninova M.,  Rötig A., Munnich A. , Venyaminova A., Tarassov I., Entelis N. (2014).
Modelling of antigenomic therapy of mitochondrial diseases by mitochondrially addressed RNA targeting a pathogenic point mutation in mtDNA.
J. Biol. Chem. 289, 13323-34. Abstract

Tonin Y., Heckel A.-M., Dovydenko I., Meschaninova M., Comte C., Venyaminova A., Pyshnyi D., Tarassov I., Entelis N. (2014).
Characterization of chemically modified oligonucleotides targeting a pathogenic mutation in human mitochondrial DNA.

Biochimie 100, 192-9. Abstract

Weber-Lotfi F., Mileshina D.V., Ibrahim N., Koulintchenko M.V., D'Souza G.G.M., Saxena V., Konstantinov Yu.M., Lightowlers R.N. and Dietrich A. (2014)
DNA import competence and mitochondrial genetics.
Biopolym. Cell 30: 71-73.

Wende S., Platzer E.G., Jühling F., Pütz J., Florentz C., Stadler P.F. and Mörl M. (2014).
Biological evidence for the world's smallest tRNAs.

Biochimie 100, 151-158. Abstract

Wolff P, Amal I, Olieric V, Chaloin O, Gygli G, Ennifar E, Lorber B, Guichard G, Wagner J, Dejaegere A, Burnouf D (2014)
Differential Modes of Peptide Binding onto Replicative Sliding Clamps from Various Bacterial Origins.
J. Med. Chem. 57: 7565-7576

2013

Bannwarth S., Procaccio V., Lebre A.S., Jardel C., Chaussenot A., Hoarau C., Maoulida H., Charrier N., Gai X., Xie H.M., Ferre M., Fragaki K., Hardy G., Mousson de Camaret B., Marlin S., Dhaenens C.M., Slama A., Rocher C., Paul Bonnefont J.,Rötig A., Aoutil N., Gilleron M., Desquiret-Dumas V., Reynier P., Ceresuela J., Jonard L., Devos A., Espil-Taris C., Martinez D., Gaignard P., Le Quan Sang K.H., Amati-Bonneau P., Falk M.J., Florentz C., Chabrol B., Durand-Zaleski I., Paquis-Flucklinger V. (2013).
Prevalence of rare mitochondrial DNA mutations in mitochondrial disorders.
J Med Genet, in press. Abstract

Bernt M., Donath A., Juhling F., Externbrink F., Florentz C., Fritzsch G., Putz J., Middendorf M. and Stadler P.F. (2013).
MITOS: Improved de novo metazoan mitochondrial genome annotation.
Mol Phylogenet Evol, 69(2), 313-9. Abstract

Cognat V., Pawlak G., Duchêne A.M., Daujat M., Gigant A., Salinas T., Michaud M., Gutmann B., Giegé P., Gobert A. and Marechal-Drouard L.
Plant RNA a database for tRNAs of photosynthetic eukaryotes.
Nucleic Acids Res., 41:273-279, 2013. Abstract

Comte C, Tonin Y, Heckel-Mager AM, Boucheham A, Smirnov A, Aure K, Lombes A, Martin RP, Entelis N, Tarassov I (2013)
Mitochondrial targeting of recombinant RNAs modulates the level of a heteroplasmic mutation in human mitochondrial DNA associated with Kearns Sayre Syndrome.
Nucleic acids research 41: 418-433

Cumbo A., Lorber B., Corvini P.F., Meier W. and Shahgaldian P. (2013).
A synthetic nanomaterial for virus recognition produced by surface imprinting.

Nat Commun 4, 1503. Abstract

Florentz C, Pütz J, Jühling F, Schwenzer H, Stadler P, Lorber B, Sauter C, Sissler M (2013)
Translation in mammalian mitochondria (part B): Order and disorder linked to tRNAs and aminoacyl-tRNA synthetases.
In: Duchêne A-M (ed) Translation in mitochondria and other organelles. Springer

Giegé P.
Pentatricopeptide repeat proteins: a set of modular RNA specific binders massively used for organelle gene expression.
RNA Biol., 14(9):1417-1418, 2013.  Abstract

Gobert A, Pinker F, Fuchsbauer O, Gutmann B, Boutin R, Roblin P, Sauter C, Giegé P. (2013).
Structural insights into protein-only RNase P complexed with tRNA.

Nat Commun 4, 1353. Full text

Gowher A, Smirnov A, Tarassov I, Entelis N (2013)
Induced tRNA import into human mitochondria: implication of a host aminoacyl-tRNA-synthetase.
PloS one 8: e66228

Michely S., Toulza E., Subirana L., Uwe J., Cognat V., Maréchal-Drouard L., Grimsley N., Moreua H. and Piganeau G. (2013)
Evolution of Codon Usage In The Smallest Photosynthetic Eukaryotes And Their Giant Viruses.
Genome Biol Evol, 5(5):848-859. Abstract

Neuenfeldt A., Lorber B., Ennifar E., Gaudry A., Sauter C., Sissler M. and Florentz C. (2013).
Thermodynamic properties distinguish human mitochondrial aspartyl-tRNA synthetase from bacterial homolog with same 3D architecture.

Nucleic Acids Res 41(4), 2698-708. Abstract

Niazi AK, Mileshina D, Cosset A, Val R, Weber-Lotfi F, Dietrich A (2013) Targeting nucleic acids into mitochondria: Progress and prospects. Mitochondrion 13: 548–558 Abstract

Nozawa K., Ishitani R., Yoshihisa T., Sato M., Arisaka F., Kanamal S., Dohmae N., Mangroo D., Senger B., Becker H.D., Nureki, O. (2013).
Crystal structure of Cex1p reveals the mechanism of tRNA trafficking between nucleus and cytoplasm.
Nucleic Acids Res. 41, 3901-3914. Abstract

Pinker F, Bonnard G, Gobert A, Gutmann B, Hammani K, Sauter C, Gegenheimer PA, Giegé P (2013)
PPR proteins shed a new light on RNase P biology.
RNA biology 10: 1457-1468 Abstract

Pinker F, Brun M, Morin P, Deman AL, Chateaux JF, Oliéric V, Stirnimann C, Lorber B, Terrier N, Ferrigno R, Sauter C (2013)
ChipX: a novel microfluidic chip for counter-diffusion crystallization of biomolecules and in situ crystal analysis at room temperature.
Crystal Growth & Design 13: 3333–3340

Saad Y.N., Stamatopoulou V., Brayé M., Drainas D., Stathopoulos C., Becker H.D. (2013).
Two-codon T-Box riboswitch binding two tRNAs.
Proc. Natl. Acad. Sci. U. S. A. 110, 12756-12761. Abstract

Salinas T., Remacle C. and Maréchal-Drouard L.. (2013)
Mitochondrial translation in green algae and higher plants
.
volume Springer, Heidelberg New York Dordrecht London.

Sissler M, Schwenzer H, Scheper G, Zorn N, Moulinier L, Gaudry A, Leize E, Martin F, Florentz C, Poch O (2013)
Evolutionary decline for a nuclear-encoded human mitochondrial aminoacyl-tRNA synthetase.
FEBS Journal 280: 543-544

Tarassov I, Chicherin I, Tonin Y, Smirnov A, Kamenski P, Entelis N (2013)
Mitochondrial targeting of RNA and mitochondrial translation.
In: Duchene A-M (ed) Translation in mitochondria and other organelles. Springer-Verlag Berlin Heidelberg, pp 85-107

van Berge L., Kevenaar J., Polder E., Gaudry A., Florentz C., Sissler M., van der Knaap M.S. and Scheper G.C. (2013).
Pathogenic mutations causing LBSL affect mitochondrial aspartyl-tRNA synthetase in diverse ways.

Biochem J 450(2), 345-50. Abstract

Zhang H., Endrizzi J.A., Shu Y., Haque F., Sauter C., Shlyakhtenko L.S., Lyubchenko Y., Guo P. and Chi Y.I. (2013).
Crystal structure of 3WJ core revealing divalent ion-promoted thermostability and assembly of the Phi29 hexameric motor pRNA.
RNA 19(9), 1226-37. Abstract

2012

Atkinson GC, Kuzmenko A, Kamenski P, Vysokikh MY, Lakunina V, Tankov S, Smirnova E, Soosaar A, Tenson T, Hauryliuk V. (2012)
Evolutionary and genetic analyses of mitochondrial translation initiation factors identify the missing mitochondrial IF3 in S. cerevisiae
.
Nucleic Acids Res. 40 (13), 6122-6134. Abstract

Belostotsky R, Frishberg Y, Entelis N (2012)
Human mitochondrial tRNA quality control in health and disease: a channelling mechanism?
RNA biology 9: 33-39 Abstract

Chibani K, Tarrago L, Gualberto JM, Wingsle G, Rey P, Jacquot JP, Rouhier N (2012)
Atypical thioredoxins in poplar: the glutathione-dependent thioredoxin-like 2.1 supports the activity of target enzymes possessing a single redox active cysteine.
Plant physiology 159: 592-605

Dietrich A, Mileshina D, Niazi AK, Cosset A, Val R, Ibrahim N, Weber-Lotfi F (2012)
Manipulating the mitochondrial genetic system
In: Poindron P, Piguet P (eds) Genetically Modified Organisms and Genetic Engineering in Research and Therapy, BioValley Monographs Karger Medical and Scientific, Basel, Switzerland, pp 103-119

Dietrich A, Rolle K, Gabryelska M, Wyszko E, Val R, Szymanski M, Valentin C, Cosset A, Barciszewski J (2012)
RNA technologies for mitochondrial genetics.
In: Erdmann VA, Barciszewski J (eds) RNA Technologies - From Nucleic Acids Sequences to Molecular Medicine. Springer-Verlag, Berlin, Heidelberg, Germany, pp 313-356

Duchene AM, Giegé P (2012)
Dual localized mitochondrial and nuclear proteins as gene expression regulators in plants?
Frontiers in plant science 3: 221 Abstract

Fischer F., Huot J.L., Lorber B., Diss G., Hendrickson T.L., Becker H.D., Lapointe, J., Kern, D. (2012).
The asparagine-transamidosome from Helicobacter pylori: a dual-kinetic mode in non-discriminating aspartyl-tRNA synthetase safeguards the genetic code.
Nucleic Acids Res. 40, 4965-4976. Abstract

Gaudry A, Lorber B, Messmer M, Neuenfeldt A, Sauter C, Florentz C, Sissler M (2012) Redesigned N-terminus enhances expression, solubility, and crystallisability of mitochondrial enzyme. Protein Engineering, Design and Selection 25: 473-481 Abstract

Giege R., Jühling F., Pütz J., Stadler P., Sauter C. and Florentz C. (2012).
Structure of transfer RNAs: similarity and variability.
Wiley Interdiscip Rev RNA 3(1), 37-61. Abstract

Gutmann B., Gobert A. and Giegé P. (2012).
PRORP proteins support RNase P activity in both organelles and the nucleus in Arabidopsis.

Genes & Dev., 26: 1022-1027. Abstract

Gutmann B, Gobert A, Giegé P (2012)
Mitochondrial genome evolution and the emergence of PPR proteins.
Advances in botanical research. Vol. Mitochondrial genome evolution (Elsevier). Mitochondrial genome evolution. Ed. by L. Drouard. : 253-313

Janicka S, Kuhn K, Le Ret M, Bonnard G, Imbault P, Augustyniak H, Gualberto JM (2012)
A RAD52-like single-stranded DNA binding protein affects mitochondrial DNA repair by recombination.
The Plant journal : for cell and molecular biology 72: 423-435

Jühling F., Pütz J., Florentz C. and Stadler P.F. (2012).
Armless mitochondrial tRNAs in enoplea (nematoda).

RNA Biol 9(9), 1161 - 1166. Abstract

Jühling F., Pütz J., Bernt M., Donath A., Middendorf M., Florentz C. and Stadler P.F. (2012).
Improved systematic tRNA gene annotation allows new insights into the evolution of mitochondrial tRNA structures and into the mechanisms of mitochondrial genome rearrangements.
Nucleic Acids Res 40(7), 2833-2845. Abstract

Kanga S, Bernard D, Mager-Heckel AM, Erpapazoglou Z, Mattiroli F, Sixma TK, Leon S, Urban-Grimal D, Tarassov I, Haguenauer-Tsapis R (2012)
A deubiquitylating complex required for neosynthesis of a yeast mitochondrial ATP synthase subunit.
PloS one 7: e38071 Abstract

Koulintchenko MV, Dietrich A, Konstantinov YM (2012)
Mitochondrial genetic transformation via biotechnological approaches or natural competence mechanism: do we have a choice?
Biopolym. Cell 28: 261–266

Lorber B., Fischer F., Bailly M., Roy H. and Kern D. (2012).
Protein Analysis by Dynamic Light Scattering: Methods and Techniques for Graduate Students.
Biochemistry and Molecular Biology Education, in press.

Maréchal-Drouard L (ed.)(2012).
Mitochondrial Genome Evolution. Series editors, J.P. Jacquot, P. Gadal,Elsevier, Amsterdam.

Michaud M, Duchêne AM (2012).
Macromolecules trafficking to plant mitochondria.
In Mitochondrial Genome Evolution. Advances in Botanical Research. L. Maréchal-Drouard (ed.) Elsevier, Amsterdam. Vol 63, pp 316-347.

Remacle C., Hamel P., Larosa V., Salinas T., Subramanian N., Bonnefoy N., Kempken F. (2012).
Transformation and nucleic acid delivery to mitochondria. In Genomics of chloroplasts and mitochondria. R. Bock (ed) Vol 35: 443-458.

Robert N., d'Erfuth I., Marmagne A., Erhardt M., Allot M., Gissot L., Monachello D., Michaud M., Duchêne A.M.,Barbier-Brygoo H., Maréchal-Drouard L., Ephritikhine G. and Filleur S. (2012).
Voltage dependent anion channels (VDACs) in Arabidopsis have a dual localization in the cell but show a disctrinct role in mitochondria. 
Plant Mol. Biol., 78: 431-446. Abstract

Saad N.Y., Schiel B., Brayé M., Heap J.T., Minton N.P., Dürre P.,  Becker, H. D. (2012)
Riboswitch (T-box)-mediated Control of tRNA-dependent Amidation in Clostridium acetobutylicum Rationalizes Gene and Pathway Redundancy for Asparagine and Asparaginyl-tRNAAsn Synthesis.
J. Biol. Chem. 287, 20382-20394. Abstract

Salinas T, Duby F, Larosa V, Coosemans N, Bonnefoy N, Motte P, Maréchal-Drouard L and Remacle C (2012).
Co-evolution of mitochondrial tRNA import and codon usage determines translational efficiency in the green alga Chlamyodomonas reinhardtii.
Plos Genet, 8(9):e1002946. Abstract

Sánchez-Puig N., Sauter C., Lorber B., Giegé R. and Moreno A. (2012).
Predicting Protein Crystallizability and Nucleation.
Protein Pept Lett 19(7), 725-731. Abstract

Sauter C., Lorber B., McPherson A. and Giegé R. (2012).
Part 4. Crystallization. Chapter 4.1. General methods.
In International Tables for Crystallography (Arnold, E., Himmel, D.M., Rossmann, M., eds.) Vol. F: Crystallography of biological macromolecules, 2nd ed., pp. 99-121. Wiley, Chichester. Full text

Smirnova EV, Lakunina VA, Tarassov I, Krasheninnikov IA, Kamenski PA (2012)
Noncanonical functions of aminoacyl-tRNA synthetases. Biochemistry.
Biokhimiia 77: 15-25 Abstract

Vedrenne V, Gowher A, De Lonlay P, Nitschke P, Serre V, Boddaert N, Altuzarra C, Mager-Heckel AM, Chretien F, Entelis N, Munnich A, Tarassov I, Rotig A (2012)
Mutation in PNPT1, which encodes a polyribonucleotide nucleotidyltransferase, impairs RNA import into mitochondria and causes respiratory-chain deficiency.
American journal of human genetics 91: 912-918

 

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Aug 3 2017

“The role of mitochondria in lifestyle and metabolic syndrome – MITOEAGLE perspectives” Date:...

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From October 9, 2017 until October 13, 2017
Brindisi, Italy
From October 9, 2017 until October 13, 2017
Brindisi, Italy