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Team 3 : Targeting and transport of macromolecules to plant mitochondria

Team leader : Laurence DROUARD


Research topics

  • tRNA import process into plant mitochondria (more)
  • mRNA trafficking at the surface of plant mitochondria (more)
  • tRNA metabolism within the plant cell (more)

Role in MitoCross

First goal

The team has recently developed a protein shuttle system to introduce any RNA into isolated mitochondria of various organisms (plant, yeast, human cells). Due to the absence of tools, mostly nothing is known on mitochondrial translation plant and human mitochondria. The possibility to address full-length mRNA into mitochondria opens the door to their potential translation and thus to the study of this important process

Second goal

As compared to mitochondrial protein import, RNA mitochondrial import is still poorly understood. For many years, our team is addressing questions on the tRNA import mechanism in plants, and we will continue to make efforts in a better understanding of several aspects (translocation, regulation) of the process.

Third goal

The vast majority of mitochondrial proteins are encode by the nuclear genome, translated on cytosolic ribosomes and directed to mitochondria. In the majority of proteins, their transfer involves a specific N-terminal extension of the protein (MTS, for Mitochondrial Targeting Sequence). Some mitochondrial imported proteins are also targeted to other cellular compartments. For example some proteins are dual targeted to mitochondria and chloroplasts, but the different targeting signals are not yet deciphered. One of these signals is the targeting of mRNA to mitochondria. Very recently, the team demonstrated that this process occurs in plants. We now want to understand th eprocess involved in mRNA sorting at the surface of mitochondria


Members

Photographies of team members : click here


Under the spotlight

Differential targeting of VDAC3 mRNA isoforms influences mitochondria morphology.
Michaud M., Ubrig E., Filleur S., Erhardt M., Ephritikhine G., Marechal-Drouard L. and Duchene A. M. 
Proc Natl Acad Sci U.S.A., 111:8991-6, (2014). Abstract

Press Release @ INSB website

This article has been selected as the "paper of the month" in November 2014 by the French Society for Biochemistry and Molecular Biology (SFBBM). More details here



IBMP website of the team

here


Useful link

The PlantRNA database compiles tRNA gene sequences retrieved from fully annotated plant nuclear, plastidial and mitochondrial genomes : click here

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