Home   >   Projects   >   Axis1

Axis 1 : mtDNA maintenance and expression

Three main aspects will be addressed:

1. mtDNA recombination, repair and heteroplasmy

Investigation of the function of the plant homologous recombination system in mt-DNA segregation and repair / Characterization of the plant mt-DNA heteroplasmy control mechanism / Investigation of the repair mechanisms of mt-DNA mutations due to ROS damages

2. mt-RNAs, maturation and expression

Investigation of mt-RNA expression and transcriptome / Analysis of the involvement of PPR proteins in RNA expression and maturation processes / Establishment of the mt-tRNA tertiary network

3. Mitochondrial translation

Structural and functional characterization of mt-aaRSs / Development of a protein-shuttle to introduce RNA into organelles / Deciphering the Gln-tRNAGln formation into organelles / Structural investigation of the mito-ribosome (Coll. M. Yusupov, IGBMC)

>> Back to the general description of the project

Search & Find

Flux RSS

Dec 7 2023

IMCBio PhD program 2024 call for proposals is open. Project submission is possible until January 8,...

RSS Feed