ARN 2012-2020

The research unit "Architecture et Réactivité de l'ARN | ARN" is one of the 3 units forming the Institut de Biologie Moléculaire et Cellulaire | IBMC in Strasbourg. It is leaded by Dr. Pascale ROMBY and comprises about 110 members from CNRS, INSERM, and UNISTRA. Members include 28 senior researchers, 12 full or assistant professors, 24 engineers and technicians, currently 13 post-doctoral fellows and 20 PhD students, and about 7 master students per year.

The unit is composed of 11 independant teams, among which team 6 of the MitoCross consortium, working on various aspects of structure/function relationships and regulatory roles of RNAs. The topics cover fundamental aspects of transcription and translation in a variety of organisms, from bacteria to mammals, as well as in viruses, along three global axes: (i) non-coding RNA molecules and their regulatory roles in viral infection and pathogenic bacteria in host/pathogen interactions; (ii) translation machineries and translation regulation, in higher eukaryotes and in human mitochondria, in healthy and pathology-related situations; (iii) bioinformatics and biophysics for RNA and protein structure and folding.

The groups interact strongly and share all facilitie (technical, scientific, and administrative) and platforms (qPCR, micro-calorimetry, fluorescence measurements, quenched-flow, crystallization robot, proteomics). They also benefit from stimulating scientific discussions along regular meetings, seminars, and scientific councils.

•  Team 6 : Mitochondrial translation and pathologies (C.Florentz & M. Sissler)

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